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RITONAVIR - Impurity

RITONAVIR  - Impurity

Impurity:RITONAVIR - Impurity

Chemical Name:gama-(S)-Amino alpha- (1S)-(thiazoly methyloxycarbonyl)-amino-(2-phenylethyl)- (S)-benzene butanol

RITONAVIR - EP Impurity A (ureidovaline ritonavir)

  RITONAVIR - EP Impurity A (ureidovaline ritonavir)

Impurity: RITONAVIR - EP Impurity A (ureidovaline ritonavir)

Chemical Name:N-[[(methyl[[2-(1-methylethyl)-4-thiazoyl]methyl]amino]carbonyl]-L-valine

RITONAVIR - EP Impurity B (n-deacylvaline ritonavir)

RITONAVIR - EP Impurity B (n-deacylvaline ritonavir)

Impurity:RITONAVIR - EP Impurity B (n-deacylvaline ritonavir)

Chemical Name:Thiazol-5-ylmethyl (2S,3S,5S)-5-[(S)-2-amino-3-methylbutanamido]-3-hydroxy-1,6-diphenylhexan-2-ylcarbamate

RITONAVIR - EP Impurity D (2,5-Thiazolylmethyl-dicarbamate)

RITONAVIR - EP Impurity D (2,5-Thiazolylmethyl-dicarbamate)

Impurity:RITONAVIR - EP Impurity D (2,5-Thiazolylmethyl-dicarbamate)

Chemical Name:Bis(thiazol-5-ylmethyl) (2S,3S,5S)-3-hydroxy-1,6-diphenylhexane-2,5-diyldicarbamate

RITONAVIR - EP Impurity E (Hydroxy-ritonavir)

RITONAVIR - EP Impurity E (Hydroxy-ritonavir)

Impurity:RITONAVIR - EP Impurity E (Hydroxy-ritonavir)

Chemical Name:Thiazol-5-ylmethyl (2S ,3S ,5S )-3-hydroxy-5-[(S )-2-(3-{[2-(2-hydroxypropan-2-yl)thiazol-4-yl]methyl}-3methylureido)3methylbutanamido]-1,6-diphenylhexan-2-ylcarbamate

RITONAVIR - EP Impurity F (Hydantoinaminoalcohol)

RITONAVIR - EP Impurity F (Hydantoinaminoalcohol)

Impurity:RITONAVIR - EP Impurity F (Hydantoinaminoalcohol)

Chemical Name:Thiazol-5-ylmethyl (2S,3S,5S)-3-hydroxy-5-[(S)-4-isopropyl-2,5-dioxoimidazolidin-1-yl]-1,6-diphenylhexan-2-ylcarbamate

RITONAVIR - EP Impurity G (Ritonavir Hydroperoxide)

RITONAVIR - EP Impurity G (Ritonavir Hydroperoxide)

Impurity:RITONAVIR - EP Impurity G (Ritonavir Hydroperoxide)

Chemical Name:Thiazol-5-ylmethyl (2S,3S,5S)-5-[(S)-2-(3-{[2-(2-hydroperoxypropan-2-yl)thiazol-4-yl]methyl}-3-methylureido)-3-methylbutanamido]-3-hydroxy-1,6-diphenylhexan-2-ylcarbamate

RITONAVIR - EP Impurity J (BOC-aminoalcohol)

RITONAVIR - EP Impurity J (BOC-aminoalcohol)

Impurity:RITONAVIR - EP Impurity J (BOC-aminoalcohol)

Chemical Name:Thiazol-5-ylmethyl (2S,3S,5S)-( 5-t-butoxycarbonylamino)-3-hydroxy-1,6-diphenylhexan-2-ylcarbamate

RITONAVIR - EP Impurity L (Oxazolidinone derivative)

RITONAVIR - EP Impurity L (Oxazolidinone derivative)

Impurity:RITONAVIR - EP Impurity L (Oxazolidinone derivative)

Chemical Name:(S)-N-[(S)-1-[(4S,5S)-4-benzyl-2-oxooxazolidin-5-yl]-3-phenylpropan-2-yl]-2-{3-[(2-isopropylthiazol-4-yl)methyl]-3-methylureido}-3-methylbutanamide

RITONAVIR - EP Impurity O (3-Epimer)

RITONAVIR - EP Impurity O (3-Epimer)

Impurity:RITONAVIR - EP Impurity O (3-Epimer)

Chemical Name:Thiazol-5-ylmethyl (2S,3R,5S)-3-hydroxy-5-[(S)-2-{3-[(2isopropylthiazol4yl)methyl]-3-methylureido}-3-methylbutanamido]-1,6-diphenylhexan-2-ylcarbamate

RITONAVIR - EP Impurity R (5-Epimer)

RITONAVIR - EP Impurity R (5-Epimer)

Impurity:RITONAVIR - EP Impurity R (5-Epimer)

Chemical Name:Thiazol-5-ylmethyl (2S,3S,5R)-3-hydroxy-5-[(S)-2-{3-[(2isopropylthiazol4yl)methyl]-3-methylureido}-3-methylbutanamido]-1,6-diphenylhexan-2-ylcarbamate

RITONAVIR - EP Impurity T (Divalinyl analog)

 RITONAVIR - EP Impurity T (Divalinyl analog)

Impurity: RITONAVIR - EP Impurity T (Divalinyl analog)

Chemical Name:(2S)-N-[(1S,2S,4S)-1-benzyl-2-hydroxy-4-[[(2S)-3-methyl-2-[[methyl[[2-(1-methylethyl)thiazol-4-yl]mehtyl]carbamoyl]amino]butanoyl]amino]-5-phenylpentyl]-3-methyl-2-[[methyl[[2-(1-methylethyl)thiazol-

RITONAVIR - EP Impurity U (O-Acyl ritonavir)

RITONAVIR - EP Impurity U (O-Acyl ritonavir)

Impurity:RITONAVIR - EP Impurity U (O-Acyl ritonavir)

Chemical Name:(S)-[(5S,8S,10S,11S)-8,11-dibenzyl-5-isopropyl-1-(2-isopropylthiazol-4-yl)-2-methyl-3,6,13-trioxo-15-(thiazol-5-yl)-14-oxa-2,4,7,12-tetraazapentadecan-10-yl] 2-{3-[(2-isopropylthiazol-4-yl)methyl]-3-

Ritonavir Impurities

Ritonavir Impurities

Impurity:Ritonavir Acetamido-alcohol

Chemical Name:Thiazol-5-ylmethyl (2S,3S,5S)-5-acetamido-3-hydroxy-1,6-diphenylhexan-2-ylcarbamate

Ritonavir Impurities

Ritonavir Impurities

Impurity:Ritonavir 2,5-Thiazolylmethyl-dicarbamate

Chemical Name:Bis(thiazol-5-ylmethyl) (2S,3S,5S)-3-hydroxy-1,6-diphenylhexane-2,5-diyldicarbamate

Ritonavir Impurities

Ritonavir Impurities

Impurity:Ritonavir Impurity-Hydroxy Ritonavir

Chemical Name:Thiazol-5-ylmethyl (2S ,3S ,5S )-3-hydroxy-5-[(S )-2-(3-{[2-(2-hydroxypropan-2-yl)thiazol-4-yl]methyl}-3-methylureido)-3-methylbutanamido]-1,6-diphenylhexan-2-ylcarbamate

Ritonavir Impurities

Ritonavir Impurities

Impurity:Ritonavir Hydantoinaminoalcohol

Chemical Name:Thiazol-5-ylmethyl (2S,3S,5S)-3-hydroxy-5-[(S)-4-isopropyl-2,5-dioxoimidazolidin-1-yl]-1,6-diphenylhexan-2-ylcarbamate

Ritonavir Impurities

Ritonavir Impurities

Impurity:Ritonavir Mixture of ureidovaline and N-decylvaline

Chemical Name:Ureidovaline is [N-methyl[(2-isopropyl-4-thiazolyl)methyl]amino]carbonyl –L-valine and N-deacylvaline ritonavir is thiazol-5-ylmethyl(2S,3S,5S)-5-[(S)-2-amino-3-methylbutanamido-3-hydroxy1,6-diphen

Ritonavir Impurities

Ritonavir Impurities

Impurity:Ritonavir 4-Hydroxy Epimer

Chemical Name:Thiazol-5-ylmethyl (2S,4S,5S)-4-hydroxy-5-[(S)-2-{3-[(2-isopropylthiazol-4-yl)methyl]-3-methylureido}-3-methylbutanamido]-1,6-diphenylhexan-2-ylcarbamate

Ritonavir Impurities

Ritonavir Impurities

Impurity:Ritonavir Divalinyl Analog

Chemical Name:(2S,2S)-N,N-[(2S,3S,5S)-3-hydroxy-1,6-diphenylhexane-2,5-diyl]bis(2-{3-[(2-isopropylthiazol-4-yl)methyl]-3-methylureido}-3-methylbutanamide)

Ritonavir Impurities

Ritonavir Impurities

Impurity:Ritonavir Valine Urea Analog

Chemical Name:(3S,4S,6S,10S,13S,15S,16S)-Bis(thiazol-5-ylmethyl)-4,15-dihydroxy-10-isopropyl-8,11-dioxo-3,6,13,16-tetrabenzyl-2,7,9,12,17-pentaazaoctadecanedioate

Ritonavir Impurities

Ritonavir Impurities

Impurity:Ritonavir Ureidovaline isobutyl ester

Chemical Name:(S)-Isobutyl 2-{3-[(2-isopropylthiazol-4-yl)methyl]-3-methylureido}-3-methyl butanoate

Ritonavir Impurities

Ritonavir Impurities

Impurity:Ritonavir Oxazolidinone derivative

Chemical Name:(S)-N-[(S)-1-[(4S,5S)-4-benzyl-2-oxooxazolidin-5-yl]-3-phenylpropan-2-yl]-2-{3-[(2-isopropylthiazol-4-yl)methyl]-3-methylureido}-3-methylbutanamide

Ritonavir Impurities

Ritonavir Impurities

Impurity:Ritonavir Ethyl analog

Chemical Name:Thiazol-5-ylmethyl)(2S,3S,5S)-5-[(S)-2-{3-[2-ethylthiazol-4-yl)methyl]-3-methylureido}-3-methylbutanamido]-3-hydroxy-1,6-diphenylhexan-2-ylcarbamate